Biomarcadores em Transtorno do Pânico

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Resultados de pesquisa realizada pelo Programa de Transtornos de Ansiedade do Hospital de Clinicas de Porto Alegre (PROTAN-HCPA) sobre Terapia Cognitivo-comportamental em pacientes com Transtorno do Pânico são publicados no Journal of Affective Disorders.

Os achados reforçam a eficácia da Terapia Cognitivo-comportamental no Transtorno do Pânico e demonstram que a melhora clínica percebida pelos pacientes (aferida por escalas psicométricas) é acompanhada da normalização de parâmetros fisiológicos alterados pelos sintomas de hiperventilação característicos dos quadros de ansiedade.




Segue abaixo o resumo original do artigo:

Respiratory subtype of panic disorder: Can serum phosphate levels be a possible outcome to group cognitive-behavior therapy?


Objective: Panic disorder (PD) respiratory subtype (RS) was described in order to cluster patients according to their symptoms. These patients are characterized by experiencing a relatively high number of noticeable respiratory symptoms during a panic attack (PA) and a higher reactivity to CO2. In this study, we aimed to evaluate the clinical relevance of this diagnostic category, evaluating if there are different responses to cognitive-behavioral therapy in patients with panic disorder RS as compared to those with the non-respiratory subtype (NRS), using serum phosphate as a biological marker.

Methods: Patients were assessed by a clinical interview followed by a structured diagnostic interview (M.I.N.I) and classified as RS or NRS based on symptoms. The severity of PD was evaluated throughout the PDSS, CGI, HAM-A, STAI and the BDI rating scales. All patients underwent 12 structured sessions of group-CBT for PD and had their blood collected at baseline and after treatment to assess phosphate levels.

Results: One hundred and thirty-eight patients have been assessed, and 102 were included in this trial. Sixty-nine patients completed the treatment protocol, 42 were classified as RS and 27 as NRS. Both RS and NRS patients improved in all clinical scales (p<0.001). The mean phosphate levels increased from 2.44 mg/dl ± 0.49 at baseline to 3.38 mg/dl ± 0.52 (p<0.01) in the RS group as well as from 2.46 mg/dl ± 0.64 at baseline to 3.46 mg/dl ± 0.61 (p<0.01) in the NSR group.

Conclusion: Our findings suggest that both RS and NRS benefit from group CBT and that there was a change in phosphate levels after effective treatment in both groups. Our data support the idea that there is a reversal of the conditions that promote hypophosphatemia as chronic hyperventilation after CBT treatment, whereas it is in disagreement to the presence of two different PD subtypes based on phosphate levels once their rates did not differ at baseline and had a similar increase after effective treatment.



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